Sodium Hydroxide → HCID 20446187, compound

Participants

Reaction Steps

A mixture of 2-oxo-7-(4-chlorophenylsulfonyl)indoline (3.3 g) and dioxane (20 ml) was added to a solution of sodium hydroxide (2.0 g) in water (20 ml), and the mixture was refluxed with stirring for 6 hrs. The reaction mixture was concentrated in vacuo, and the residue was dissolved in water. The aqueous solution was washed with diethyl ether, adjusted to pH 4 with 5% sulfuric acid and extracted with diethyl ether. The extract was washed with saline, dried over magnesium sulfate, treated with charcoal and then evaporated in vacuo to give 2-[2-amino-3-(4-chlorophenylsulfonyl)phenyl]acetic acid (2.8 g). mp 139°-141° C.

Provenance & Evidence