Potassium Hydroxide → HCID 20446304, compound

HRID 2418399Notes

Reaction equation

HRID 2418399 reaction equation
[N+:1]([C:4]1[C:14]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])=[CH:13][CH:12]=[CH:11][C:5]=1[C:6]([O:8]CC)=[O:7])([O-:3])=[O:2].[OH-].[K+]>C(O)C>[N+:1]([C:4]1[C:14]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])=[CH:13][CH:12]=[CH:11][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 20446220HCID 20446220, compound

Product 1

HCID 20446304HCID 20446304, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-nitro-3-(2-chlorophenoxy)benzoate was suspended in 1N-potassium hydroxide (60 ml) and ethanol (60 ml) and stirred for 1.7 hrs. Ethanol was distilled off from the reaction mixture, and the remaining aqueous solution was washed with diethyl ether and acidified at 0° C. The precipitating crystals were collected by filtration, washed with water and dried over phosphorus pentoxide in vacuo to give 2-nitro-3-(2-chlorophenoxy)benzoic acid (11.3 g). mp 185°-187° C.

Workup

  1. distillationEthanol was distilled off from the reaction mixture
  2. washthe remaining aqueous solution was washed with diethyl ether
  3. customacidified at 0° C
  4. filtrationThe precipitating crystals were collected by filtration
  5. washwashed with water
  6. dry with materialdried over phosphorus pentoxide in vacuo

Sources & evidence

ORD record
ord-891fc15242a549a8877cbce946766041
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

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