HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → HCID 178500038, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (S)-1-(2-Oxopropanoyl)pyrrolidine-2-carboxylic acid | HCID 10130260 | — |
| Reactant | HCID 178501495 | HCID 178501495 | — |
| Product | HCID 178500038 | HCID 178500038 | — |
Reaction Steps
In a manner similar to Example 16, L-histidine methyl ester is condensed with pyruvoyl-L-proline in the presence of sodium cyano borohydride to yield N-[1-methoxycarbonyl-2-(1H-imidazol-4-yl)ethyl]-DL-alanyl-L-proline. The nmr spectrum in D2O shows the imidazole protons at 8.6 and 7.3; the protons adjacent to the imidazole and the methyl ester protons at 3.7 and the alanyl methyl at 1.1 to 1.38.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472380 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-a4306c5dc5864ba98b4297631155d7a9 |
| Source note | uspto-grants-1984_09 |