HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Ethyl norfloxacin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate | HCID 12733855 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl norfloxacin | HCID 12733941 | 81% |
Reaction Steps
Anhydrous piperazine (10.3 g) and 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester were added to a mixture of pyridine (9 ml) and toluene (18 ml), and the mixture was refluxed with stirring for 5 hrs. The same procedure as described in Example 1 was followed to give 8.4 g (81% yield) of 1-ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester. mp: 178.5°-180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472579 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-3e97d868a0124c268975c6dfb5d2d820 |
| Source note | uspto-grants-1984_09 |