Morpholine → HCID 136114357, compound

Participants

Reaction Steps

In 4 ml of pyridine were dissolved 200 mg of ethyl 5-chloroacetoxybenzo[a]phenazine-6-carboxylate and 220 mg of morpholine, and the solution was heated at 80°-100° C., for 3 hours. The reaction mixture was evaporated to dryness under reduced pressure. Water was added, and the precipitated solid was collected to give 130 mg (71.1% yield) of 5-hydroxy-6-morpholinocarbonylbenzo[a]phenazine as red amorphous powder, m.p. 223°-225° C., Anal. Calcd. (%) for C21H17N2O3 : C, 70.18; H, 4.77; N, 11.69; Found: C, 69.94; H, 4.86; N, 11.86

Provenance & Evidence