Methanol → Methyl 4-chloroacetoacetate

HRID 2418482노트

반응식

HRID 2418482 반응식
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[CH3:9][OH:10]>C(=O)(O)[O-].[Na+]>[CH3:9][O:10][C:4](=[O:6])[CH2:3][C:2]([CH2:7][Cl:8])=[O:5]

참가 물질

4

반응물 2

HCID 887MethanolHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

생성물 1

HCID 36240Methyl 4-chloroacetoacetate

시약·촉매·용매 1

HCID 516892Sodium Bicarbonate용매

실험 절차

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 200 parts of methanol containing 4.2 parts of anhydrous sodium bicarbonate. After stirring for 20 hours at room temperature, the solids are filtered off, the filtrate is evaporated and the residue distilled to give methyl-γ-chloroacetoacetate, b.p. 48°-50° C./0.8 mb.

후처리

  1. filtrationthe solids are filtered off
  2. customthe filtrate is evaporated
  3. distillationthe residue distilled

출처 및 근거

ORD 기록
ord-f4d83ff76a0c47e19a5a0dcaca20dabd
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04472589

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