Aniline → Butanamide, 4-chloro-3-oxo-N-phenyl-

HRID 2418483노트

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HRID 2418483 반응식
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)Cl.C(=O)(O)[O-].[Na+]>[Cl:8][CH2:7][C:2](=[O:5])[CH2:3][C:4]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:6]

참가 물질

5

반응물 2

HCID 6115AnilineHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

생성물 1

HCID 38215Butanamide, 4-chloro-3-oxo-N-phenyl-

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 516892Sodium Bicarbonate용매

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온도
0 °C

실험 절차

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 150 parts of methylenechloride containing 4.2 parts of anhydrous sodium bicarbonate and the solution is cooled to 0° C. 4.7 Parts of aniline are then added over 30 minutes and the reaction mixture is finally stirred for 48 hours at room temperature. The solids are then filtered off and the filtrate evaporated. The residue is crystallised twice from chloroform to give γ-chloroacetoacetanilide, m.p. 142°-143° C.

후처리

  1. filtrationThe solids are then filtered off
  2. customthe filtrate evaporated
  3. customThe residue is crystallised twice from chloroform

출처 및 근거

ORD 기록
ord-c87d1c74da7b487382e536c1f2e9ad1f
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04472589

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