HuagongsheHuagongshe Chemistry Print Report · For research reference only
BocPro-Phe-PheNHNH2 → HCID 131713694, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | BocPro-Phe-PheNHNH2 | HCID 131713695 | — |
| Reactant | HCID 131713696 | HCID 131713696 | — |
| Product | HCID 131713694 | HCID 131713694 | 66% |
Reaction Steps
Condensation of BocPro-Phe-PheNHNH2 (1.31 g.) and HDAla-Leu-MetNH2 (0.85 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-Phe-Phe-DAla-Leu-MetNH2 in 66% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-DAla-Leu-MetNH2 (1.10 g.) using hydrogen chloride in acetic acid gave HPro-Phe-Phe-DAla-Leu-MetNH2, which was isolated as the amorphous white solid phosphate (1:1) salt sesquihydrate in 66% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-8413f03bb37f4e2db08e11d520a1c20d |
| Source note | uspto-grants-1984_09 |