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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418532Generated: November 1, 2026

Dicyclohexylcarbodiimide → BocPro-Phe-MePhe-Gly-Leu-MetNH2

https://huagongshe.com/reaction/2418532

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
ReactantN-HydroxysuccinimideHCID 80170—
ReactantBocPro-Phe-MePhe-GlyOHHCID 131713702—
ReactantHLeu-MetNH2 hydrochlorideHCID 131713703—
ProductBocPro-Phe-MePhe-Gly-Leu-MetNH2HCID 131713701100%

Reaction Steps

Condensation of BocPro-Phe-MePhe-GlyOH (0.76 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 0.39 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-Phe-MePhe-Gly-Leu-MetNH2 in 100% yield. De-t-butoxycarbonylation of BocPro-Phe-MePhe-Gly-Leu-MetNH2 (1.07 g.) using hydrogen chloride in acetic acid gave HPro-Phe-MePhe-Gly-Leu-MetNH2, which was isolated as the amorphous white solid phosphate (1:1) salt dihydrate in 22% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-715fe5a9b14646dc8ec12ffb084b5fe9
Source noteuspto-grants-1984_09