HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HPro-Phe-Phe-Gly-DLeu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 131713709 | HCID 131713709 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HPro-Phe-Phe-Gly-DLeu-MetNH2 | HCID 131713710 | — |
Reaction Steps
Condensation of BocPro-Phe-PheNHNH2 (Example 1, 0.93 g.) and HGly-DLeu-MetNH2 (0.63 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-Phe-Phe-Gly-DLeu-MetNH2 in 59% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-Gly-DLeu-MetNH2 (0.88 g.) using hydrogen chloride in acetic acid gave HPro-Phe-Phe-Gly-DLeu-MetNH2, which was isolated as the amorphous white solid phosphate (1:1) salt in 59% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-3409d42df300495398958cdd0e294075 |
| Source note | uspto-grants-1984_09 |