HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HPro-Phe-Phe-Gly-MeLeu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 131713714 | HCID 131713714 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HPro-Phe-Phe-Gly-MeLeu-MetNH2 | HCID 131713713 | 36% |
Reaction Steps
Condensation of BocPro-Phe-Phe-GlyOH (2.8 g.) and MeLeu-MetNH2 (1.6 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-Phe-Phe-Gly-MeLeu-MetNH2 in 49% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-GlyMeLeu-MetNH2 using hydrogen chloride in acetic acid gave HPro-Phe-Phe-Gly-MeLeu-MetNH2, which was isolated as the amorphous white solid free base in 36% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-6aaf950c323e4792bac37a19be1a18ea |
| Source note | uspto-grants-1984_09 |