HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HPro-Phe-Phe-Gly-Leu-DMetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 131713716 | HCID 131713716 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HPro-Phe-Phe-Gly-Leu-DMetNH2 | HCID 131713717 | — |
Reaction Steps
Condensation of BocPro-Phe-PheNHNH2 (Example 1, 1.93 g.) and HGly-Leu-DMetNH2 (1.31 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-Phe-Phe-Gly-Leu-DMetNH2 in 60% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-Gly-Leu-DMetNH2 (1.6 g.) using hydrogen chloride in acetic acid gave HPro-Phe-Phe-Gly-Leu-DMetNH2, which was isolated as the amorphous white solid phosphate (1:1) slat sesquihydrate in 72% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-6df1312bebc94708b73d56f4f955cbed |
| Source note | uspto-grants-1984_09 |