HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → H-Gly-Leu-Met-Nh2 HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | BocGly-Leu-MetNH2 | HCID 15602549 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | H-Gly-Leu-Met-Nh2 HCl | HCID 13386697 | 56% |
Reaction Steps
Condensation of BocGlyOH (4.4 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 7.5 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocGly-Leu-MetNH2 in 51% yield. De-t-butoxycarbonylation of BocGly-Leu-MetNH2 using hydrogen chloride in acetic acid gave HGly-Leu-MetNH2 hydrochloride salt in 56% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-502a77d5f98d40a88cad9b7eaf0c445d |
| Source note | uspto-grants-1984_09 |