HuagongsheHuagongshe Chemistry Print Report · For research reference only
H-Gly-Leu-Met-Nh2 HCl → BocPro-Phe-Phe-Gly-Leu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | H-Gly-Leu-Met-Nh2 HCl | HCID 13386697 | — |
| Reactant | BocPro-Phe-DPheNHNH2 | HCID 131713720 | — |
| Product | BocPro-Phe-Phe-Gly-Leu-MetNH2 | HCID 15098075 | 79% |
Reaction Steps
Condensation of BocPro-Phe-DPheNHNH2 (2.44 g.) and HGly-Leu-MetNH2 hydrochloride salt (1.6 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-Phe-Phe-Gly-Leu-MetNH2 in 79% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-Gly-Leu-MetNH2 using hydrogen chloride in acetic acid gave HPro-Phe-Phe-Gly-Leu-MetNH2, which was isolated as the amorphous white solid hydrochloride salt monohydrate in 31% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-f3988337ebab40b78d4a9595e7802fe1 |
| Source note | uspto-grants-1984_09 |