HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HPro-Phe-Phe-Gly-Leu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | BocPro-Phe-Phe-Gly-Leu-MetNH2 | HCID 15098075 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HPro-Phe-Phe-Gly-Leu-MetNH2 | HCID 131713721 | — |
Reaction Steps
Condensation of BocPro-Phe-DPheNHNH2 (2.44 g.) and HGly-Leu-MetNH2 hydrochloride salt (1.6 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-Phe-Phe-Gly-Leu-MetNH2 in 79% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-Gly-Leu-MetNH2 using hydrogen chloride in acetic acid gave HPro-Phe-Phe-Gly-Leu-MetNH2, which was isolated as the amorphous white solid hydrochloride salt monohydrate in 31% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-c13a8d0f364b4ba88b9588d14b50ee8d |
| Source note | uspto-grants-1984_09 |