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HRID2418557

反应详情

EQUATION

反应方程式

HRID 2418557 的结构方程式

REACTANTS

反应物

2
结构：N[C@H](Cc1ccccc1)C(=O)O
HCID71567

D-Phenylalanine

C9H11NO2

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)ON1C(=O)CCC1=O
HCID853883

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O
HCID7019894

未命名化合物

收率 67%

PROCEDURE

实验过程

Condesation of BocProOH (6.46 g.) and N-hydroxysuccinimide (3.5 g.) using dicyclohexylcarbodiimide gave BocProOSu in 75% yield. Condensation of BocProOSu (5.0 g.) and HDPheOH (2.75 g.) by the salt coupling method gave BocPro-DPheOH in 67% yield. Condensation of BocPro-DPheOH (3.98 g.) and HPheOMe hydrochloride salt (2.4 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-DPhe-PheOMe in 74% yield. Hydrazinolysis of Boc-Pro-DPhe-PheOMe (3.14 g.) gave BocPro-DPhe-PheNHNH2 in 79% yield.