HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenylphosphinic chloride → HCID 131713734, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenylphosphinic chloride | HCID 73910 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | HCID 131713735 | HCID 131713735 | — |
| Product | HCID 131713734 | HCID 131713734 | 73% |
Reaction Steps
Condensation of BocPheOPFP (8.63 g.) and MePHeOMe (5.50 g.) by the active ester method gave BocPhe-MePheOMe in 95% yield. De-t-butoxycarbonylation of BocPhe-MePheOMe using hydrogen chloride in ethyl acetate gave HPhe-MePHeOMe in 48% yield. Condensation of BocProOH (0.71 g.) and HPhe-MePheOMe (1.13 g.) by the mixed anhydride method using diphenylphosphinic chloride gave BocPro-Phe-MePheOMe in 73% yield. Hydrazinolysis of BocPro-Phe-MePheOMe (3.10 g.) gave BocPro-Phe-MePheNHNH2 in 84% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-244299fd3b624040a6d4e7b96aa51aa2 |
| Source note | uspto-grants-1984_09 |