HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 131713736, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 131713737 | HCID 131713737 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131713736 | HCID 131713736 | — |
Reaction Steps
Condensation of BocPro-Phe-MePheNHNH2 (0.86 g.) and HSar-Leu-MetNH2 (Example 3, 0.63 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-Phe-MePhe-Sar-Leu-MetNH2 in 75% yield. De-t-butoxycarbonylation of BocPro-Phe-MePhe-Sar-Leu-MetNH2 (0.90 g.) using trifluoroacetic acid in methylene dichloride gave HPro-Phe-MePhe-Gly-Leu-MetNH2, which was isolated as the amorphous white solid phosphate (1:1) salt in 59% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-3df8c4aa9888401098c4034dd6a037ce |
| Source note | uspto-grants-1984_09 |