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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418565Generated: October 31, 2026

Trifluoroacetic acid → HCID 131713738, compound

https://huagongshe.com/reaction/2418565

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 131713739HCID 131713739—
ProductHCID 131713738HCID 13171373881%

Reaction Steps

Condensation of BocTrpOPFP (1.41 g.) and HLeu-Met-NH2 hydrochloride salt (Example 1, 0.89 g.) by the activated ester method gave BocTrp-Leu-MetNH2 in 81% yield. De-t-butoxycarbonylation of BocTrp-Leu-MetNH2 (1.06 g.) using trifluoroacetic acid containing 10% water gave Htrp-Leu-MetNH2 in 81% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-5a33ae192fc64e16b27ad155541e516f
Source noteuspto-grants-1984_09