HuagongsheHuagongshe Chemistry Print Report · For research reference only
BocPro-DPhe-PheNHNH2 → BocPro-DPhe-Phe-Trp-Leu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | BocPro-DPhe-PheNHNH2 | HCID 131713729 | — |
| Reactant | HTrp-Leu-MetNH2 | HCID 131713741 | — |
| Product | BocPro-DPhe-Phe-Trp-Leu-MetNH2 | HCID 131713740 | 97% |
Reaction Steps
Condensation of BocPro-DPhe-PheNHNH2 (Example 9, 477 mg.) and HTrp-Leu-MetNH2 (510 mg.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-DPhe-Phe-Trp-Leu-MetNH2 in 97% yield. De-t-butoxycarbonylation of BocPro-DPhe-Phe-Trp-Leu-MetNH2 (0.80 g.) using trifluoroacetic acid containing 10% water gave HPro-DPhe-Phe-DTrp-Leu-MetNh2, which was isolated as the amorphous white solid phosphate (1:2) salt tetrahydrate in 32% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-b643f50b70b549389a31baf28365044e |
| Source note | uspto-grants-1984_09 |