huagongshe.com
HRID2418567

反应详情

EQUATION

反应方程式

HRID 2418567 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NC[C@H](N)C(=O)O
HCID10352859

3-[(tert-Butoxycarbonyl)amino]-L-alanine

C8H16N2O4

结构：O=C(N[C@@H](Cc1ccccc1)C(=O)ON1C(=O)CCC1=O)OCc1ccccc1
HCID12876457

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)O
HCID131713742

未命名化合物

收率 64%

PROCEDURE

实验过程

Condensation of ZPheOSu (6.96 g.) and HLDap(Boc)OH (6.0 g.) by the salt coupling method gave ZPhe-LDap(Boc)OH in 64% yield. Condensation of ZPhe-LDap(Boc)OH (4.85 g.) and HLeuOMe (2.73 g.) by the mixed anhydride method using diphenylphosphinic chloride gave ZPhe-LDap(Boc)-LeuOMe in 69% yield. Debenzyloxycarbonylation of ZPhe-LDap(Boc)-LeuOMe (4.15 g.) by hydrogenation with palladium catalyst gave HPhe-LDap(Boc)-LeuOMe in 100% yield. Condensation of BocPro-PheOH (1.09 g.) and HPhe-LDap(Boc)-LeuOMe (1.44 g.) using dicyclohexylcarbodiimide and N-hydroxynorbornenedicarboximide gave BocPro-Phe-Phe-LDap(Boc)-LeuOMe in 75% yield. Hydrazinolysis of BocPro-Phe-Phe-LDap(Boc)-LeuOMe (1.69 g.) gave BocPro-Phe-Phe-LDap(Boc)- LeuNHNH2 in 36% yield.