HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HPro-Phe-Phe-LDap-Leu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 131713745 | HCID 131713745 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HPro-Phe-Phe-LDap-Leu-MetNH2 | HCID 131713744 | — |
Reaction Steps
Condensation of BocPro-Phe-Phe-LDap(Boc)-LeuNHNH2 (607 mg.) and HMetNH2 (150 mg.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-Phe-Phe-LDap(Boc)-Leu-MetNH2 in 67% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-LDap(Boc)-Leu-MetNH2 (430 mg.) using hydrogen chloride in acetic acid gave HPro-Phe-Phe-LDap-Leu-MetNH2, which was isolated as the amorphous white solid phosphate (1:2) salt dihydrate in 95% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-48874befaa694071ae07f58fbc35ddd4 |
| Source note | uspto-grants-1984_09 |