HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131713751, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 131713753 | HCID 131713753 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 131713751 | HCID 131713751 | — |
Reaction Steps
Condensation of BocPro-Phe-Phe-GlyOH (1.61 g.) and HGal-MetNH2 dihydrochloride salt (0.70 g.) using dicyclohexylcarbodiimide and 4-dimethylaminopyridine as catalyst gave BocPro-Phe-Phe-Gly-Gal-MetNH2 in 28% yield. De-t-butoxycarbonylation of BocPro-Phe-Phe-Gly-Gal-MetNH2 (0.44 g.) using hydrogen chloride in acetic acid gave HPro-Phe-Phe-Gly-Gal-MetNH2, which was isolated as the amorphous white solid dihydrochloride acetate salt hydrate in 35% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-8de528dfaf4a4dde841ac2f27c6ab83c |
| Source note | uspto-grants-1984_09 |