Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418575Generated: October 27, 2026

Trifluoroacetic acid → HDTrp-Leu-MetNH2 trifluoroacetate

https://huagongshe.com/reaction/2418575

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantBocDTrp-Leu-MetNH2HCID 131713756—
ProductHDTrp-Leu-MetNH2 trifluoroacetateHCID 13171375550%

Reaction Steps

Condensation of BocDTrpOPFP (2.35 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 1.49 g.) by the activated ester method gave BocDTrp-Leu-MetNH2 in 71% yield. De-t-butoxycarbonylation of BocDTrp-Leu-MetNH2 (1.75 g.) using trifluoroacetic acid gave HDTrp-Leu-MetNH2 trifluoroacetate salt in 50% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-b177be44b66e4b97b0d1a2da3b5e180c
Source noteuspto-grants-1984_09