反应详情

A mixture of palladium on carbon (10%, 4.0 g.) in ethanol (20 ml.) was added to a solution of BocPro-DTrp-PheOBz (70.44 mmole.) in methanol (100 ml.). The mixture was diluted to 200 ml. with methanol, hydrogenated under pressure for three hours and filtered. The filtrate was stripped of volatiles. After unsuccessful attempts to crystallize the residue from ether-hexane and methanol-water it was twice dissolved in, and stripped of, chloroform and dried under high vacuum, affording BocPro-DTrp-PheOH in 95% yield as a foam (36.6 g.).

1. additionThe mixture was diluted to 200 ml
2. filtrationfiltered
3. customAfter unsuccessful attempts to crystallize the residue from ether-hexane and methanol-water it
4. dissolutionwas twice dissolved in, and
5. customdried under high vacuum