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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418586Generated: November 1, 2026

Hydrochloric Acid → HDPhe-Leu-MetNH2 hydrochloride

https://huagongshe.com/reaction/2418586

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantBocDPhe-Leu-MetNH2HCID 131713767—
SolventEthyl AcetateHCID 8857—
ProductHDPhe-Leu-MetNH2 hydrochlorideHCID 13171376882%

Reaction Steps

Condensation of BocDPheOH (2.65 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 2.98 g.) by the mixed anhydride method using isobutyl chloroformate gave BocDPhe-Leu-MetNH2 in 57% yield. De-t-butoxycarbonylation of BocDPhe-Leu-MetNH2 (2.7 g.) using hydrogen chloride in ethyl acetate gave HDPhe-Leu-MetNH2 hydrochloride salt in 82% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-06047177a7764c63ad9f21c85d9b39c5
Source noteuspto-grants-1984_09