HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 10781398, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 10645358 | HCID 10645358 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 10781398 | HCID 10781398 | 100% |
Reaction Steps
Condensation of BocDPhgOH (5.0 g.) and HPheOMe hydrochloride salt (4.3 g.) by the mixed anhydride method using isobutyl chloroformate gave BocDPhg-PheOMe in 98% yield. De-t-butoxycarbonylation of BocDPhg-PheOMe (4.23 g.) using hydrogen chloride in ethyl acetate gave HDPhg-PheOMe in 100% yield. Condensation of BocProOPFP (3.81 g.) and HDPhg-PheOMe hydrochloride salt (3.5 g.) by the activated ester method gave BocPro-DPhg-PheOMe in 74% yield. Hydrazinolysis of Bocpro-DPhg-PheOMe (3.57 g.) gave BocPro-DPhg-PheNHNH2 in 80% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-16859f53302d42508c381ce0c696befe |
| Source note | uspto-grants-1984_09 |