Hydrochloric Acid → 3-Azido-3-(6-(trifluoromethyl)pyridin-3-yl)propanal

Participants

Reaction Steps

A solution of 5-(1-azido-2-(1,3-dioxolan-2-yl)ethyl)-2-(trifluoromethyl)pyridine (7.44 g, 25.8 mmol) in tetrahydrofuran (60 mL) was treated with 20% aq. HCl (60 mL) at 0° C. The mixture was stirred at room temperature for 1.5 hours. After completion of the reaction, ethyl ether was added and the organic layer was separated, dried over MgSO4, and concentrated to give a crude oil without further purification.

Provenance & Evidence