HuagongsheHuagongshe Chemistry Print Report · For research reference only
BocPro-DPhe-PheNHNH2 → BocPro-DPhe-Phe-DPhe-Leu-NleNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | BocPro-DPhe-PheNHNH2 | HCID 131713729 | — |
| Reactant | HDPhe-Leu-NleNH2 hydrochloride | HCID 131713780 | — |
| Product | BocPro-DPhe-Phe-DPhe-Leu-NleNH2 | HCID 131713782 | 51% |
Reaction Steps
Condensation of BocPro-DPhe-PheNHNH2 (Example 23, 0.717 g.) and HDPhe-Leu-NleNH2 hydrochloride salt (0.585 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-DPhe-Phe-DPhe-Leu-NleNH2 in 51% yield. De-t-butoxycarbonylation of BocPro-Dphe-Dphe-Leu-NleNH2 (0.500 g.) using hydrogen chloride in acetic acid gave HPro-DPhe-Phe-DPhe-Leu-NleNH2, which was isolated as the amorphous white solid hydrochloride salt trihydrate in 36% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-02449cac0e4c4faeb67730e0dc26db1b |
| Source note | uspto-grants-1984_09 |