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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418595Generated: November 1, 2026

Dicyclohexylcarbodiimide → FmocDLys(Boc)-Leu-MetNH2

https://huagongshe.com/reaction/2418595

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
Reactant1-HydroxybenzotriazoleHCID 75771—
Reactant(2R)-6-(((tert-butoxy)carbonyl)amino)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acidHCID 13585941—
ReactantHLeu-MetNH2 hydrochlorideHCID 131713703—
ProductFmocDLys(Boc)-Leu-MetNH2HCID 13171378387%

Reaction Steps

Condensation of FmocDLys(Boc)OH (1.00 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 0.63 g.) using dicyclohexylcarbodiimide and 1-hydroxybenzotriazole gave FmocDLys(Boc)-Leu-MetNH2 in 87% yield. De-9-fluorenylmethoxycarbonylation of FmocDLys(Boc)-Leu-MetNH2 (1.00 g.) using piperidine in dimethylformamide gave HDLys(Boc)-Leu-MetNH2 in 100% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-2655aed522b449ecaffa0aab6ded66d9
Source noteuspto-grants-1984_09