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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418596Generated: October 30, 2026

Piperidine → HDLys(Boc)-Leu-MetNH2

https://huagongshe.com/reaction/2418596

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidineHCID 8082—
ReactantFmocDLys(Boc)-Leu-MetNH2HCID 131713783—
SolventDimethylformamideHCID 6228—
ProductHDLys(Boc)-Leu-MetNH2HCID 131713784100%

Reaction Steps

Condensation of FmocDLys(Boc)OH (1.00 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 0.63 g.) using dicyclohexylcarbodiimide and 1-hydroxybenzotriazole gave FmocDLys(Boc)-Leu-MetNH2 in 87% yield. De-9-fluorenylmethoxycarbonylation of FmocDLys(Boc)-Leu-MetNH2 (1.00 g.) using piperidine in dimethylformamide gave HDLys(Boc)-Leu-MetNH2 in 100% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-55641fda530143e6a71b98c8d01a7dbd
Source noteuspto-grants-1984_09