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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418598Generated: November 3, 2026

Dicyclohexylcarbodiimide → HCID 178503709, compound

https://huagongshe.com/reaction/2418598

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
Reactant1-HydroxybenzotriazoleHCID 75771—
ReactantHLeu-MetNH2 hydrochlorideHCID 131713703—
ReactantHCID 178427598HCID 178427598—
ProductHCID 178503709HCID 17850370954%

Reaction Steps

Condensation of BocDArg(Tos)OH (2.14 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 1.49 g.) using dicyclohexylcarbodiimide and 1-hydroxybenzotriazole gave BocDArg(Tos)-Leu-MetNH2 in 54% yield. De-t-butoxycarbonylation of BocDArg(Tos)-Leu-MetNH2 (1.7 g.) using hydrogen chloride in dioxane gave HDArg(Tos)-Leu-MetNH2 in 45% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-5218ec8967044e99b0715a5975325eee
Source noteuspto-grants-1984_09