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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418604Generated: November 1, 2026

Dicyclohexylcarbodiimide → BocPro-DTrp-Phe-DTrp-MeLeu-MetNH2

https://huagongshe.com/reaction/2418604

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
ReactantN-HydroxysuccinimideHCID 80170—
ReactantBocPro-DTrp-PheOHHCID 131713758—
ReactantHDTrp-MeLeu-MetNH2HCID 131713791—
ProductBocPro-DTrp-Phe-DTrp-MeLeu-MetNH2HCID 13171379364%

Reaction Steps

Condensation of BocPro-DTrp-PheOH (Example 33, 1.65 g.) and HDTrp-MeLeu-MetNH2 (1.34 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-DTrp-Phe-DTrp-MeLeu-MetNH2 in 64% yield. De-t-butoxycarbonylation of BocPro-DTrp-Phe-DTrp-MeLeu-MetNH2 (1.70 g.) using trifluoroacetic acid in dimethyl sulfide and ethanedithiol gave HPro-DTrp-Phe-DTrp-MeLeu-MetNH2, which was isolated as the amorphous white solid phosphate (1:1) salt tetrahydrate in 67% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-4cb83c85ba774546b0274a2a481c77c0
Source noteuspto-grants-1984_09