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HRID2418612

反应详情

EQUATION

反应方程式

HRID 2418612 的结构方程式

REACTANTS

反应物

2
结构：N[C@H](Cc1c[nH]c2ccccc12)C(=O)O
HCID9060

D-Tryptophan

C11H12N2O2

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)ON1C(=O)CCC1=O
HCID853883

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O
HCID131713757

未命名化合物

收率 70%

PROCEDURE

实验过程

Condensation of BocProOSu (6.00 g.) and HDTrpOH (4.08 g.) by the salt coupling method gave BocPro-DTrpOH in 70% yield. Condensation of BocPro-DTrpOH (2.93 g.) and HGlyOBz p-toluenesulfonate salt (2.47 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-DTrp-GlyOBz in 68% yield. Debenzylation of BocPro-DTrp-GlyOBz by hydrogenation with palladium catalyst gave BocPro-DTrp-GlyOH in 95% yield.