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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418613Generated: October 26, 2026

Trifluoroacetic acid → HDTrp-Leu-MetNH2 trifluoroacetate

https://huagongshe.com/reaction/2418613

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantBocDTrp-Leu-MetNH2HCID 131713756—
SolventEthyl methyl sulfideHCID 12230—
Solvent1,1-EthanedithiolHCID 33645—
ProductHDTrp-Leu-MetNH2 trifluoroacetateHCID 13171375523%

Reaction Steps

Condensation of BocDTrpOPFP (8.60 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 5.44 g.) by the activated ester method gave BocDTrp-Leu-MetNH2 in 67% yield. De-t-butoxycarbonylation of BocDTrp-Leu-MetNH2 (6.69 g.) using trifluoroacetic acid in methyl ethyl sulfide and ethanedithiol gave HDTrp-Leu-MetNH2 trifluoroacetate salt in 23% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-61fdc32b2888445d9cfb55f8896090df
Source noteuspto-grants-1984_09