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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418614Generated: October 27, 2026

Dicyclohexylcarbodiimide → BocPro-DTrp-Gly-DTrp-Leu-MetNH2

https://huagongshe.com/reaction/2418614

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
ReactantN-HydroxysuccinimideHCID 80170—
ReactantHDTrp-Leu-MetNH2 trifluoroacetateHCID 131713755—
ReactantBocPro-DTrp-GlyOHHCID 131713804—
ProductBocPro-DTrp-Gly-DTrp-Leu-MetNH2HCID 13171380336%

Reaction Steps

Condensation of BocPro-DTrp-GlyOH (1.00 g.) and HDTrp-Leu-MetNH2 trifluoroacetate salt (1.10 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-DTrp-Gly-DTrp-Leu-MetNH2 in 36% yield. De-t-butoxycarbonylation of BocPro-DTrp-Gly-DTrp-Leu-MetNH2 (0.68 g.) using trifluoroacetic acid in methyl ethyl sulfide and ethanedithiol gave HPro-DTrp-Gly-DTrp-Leu-MetNH2, which was isolated as the amorphous white solid phosphate (2:3) salt in 59% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-daf41efc11db48e987535baa8eed2e3c
Source noteuspto-grants-1984_09