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HRID2418616

反应详情

EQUATION

反应方程式

HRID 2418616 的结构方程式

REACTANTS

反应物

3
结构：O=P(Cl)(c1ccccc1)c1ccccc1
HCID73910

Diphenylphosphinic chloride

C12H10ClOP

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O
HCID85083

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

C10H17NO4

结构：CN[C@@H](Cc1ccccc1)C(=O)OC
HCID7021804

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C
HCID131713806

未命名化合物

收率 77%

PROCEDURE

实验过程

Condensation of BocProOH (4.30 g.) and HMePheOMe (2.74 g.) by the mixed anhydride method using diphenylphosphinyl chloride gave BocPro-MePheOMe in 77% yield. Demethylation of BocPro-MePheOMe (3.0 g.) using aqueous sodium hydroxide gave BocPro-MePheOH in 83% yield. Condensation of BocPro-MePheOH (1.71 g.) and HPheOBz (2.14 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-MePhe-PheOBz in 76% yield. Debenzylation of BocPro-MePhe-PheOBz (2.0 g.) by hydrogenation with palladium catalyst gave BocPro-MePhe-PheOH in 100% yield.