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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418622Generated: November 1, 2026

Trifluoroacetic acid → HDTrp-Leu-MeNleNH2

https://huagongshe.com/reaction/2418622

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantBocDTrp-Leu-MeNleNH2HCID 131713814—
SolventDimethyl SulfideHCID 1068—
Solvent1,1-EthanedithiolHCID 33645—
ProductHDTrp-Leu-MeNleNH2HCID 13171381537%

Reaction Steps

Condensation of BocDTrp-LeuOH (Example 38, 2.09 g.) and MeNleNH2 (1.00 g.) using dicyclohexylcarbodiimide and 1-hydroxybenzotriazole gave BocDTrp-Leu-MeNleNH2 in 99% yield. De-t-butoxycarbonylation of BocDTrp-Leu-MeNleNH2 (2.50 g.) using trifluoroacetic acid in dimethyl sulfide and ethanedithiol gave HDTrp-Leu-MeNleNH2 in 37% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04472305
Source datasetuspto-grants-1984_09
ORD IDord-1e3cb4d3d4614011b0c1bcb9efd31140
Source noteuspto-grants-1984_09