反应详情

温度

-30 °C

0.23 mole (43 g) of 2-chloro-5-acetylamino phenol is dissolved, with agitation, in 500 cc of sulfuric acid (d=1.83) at a temperature of about +5° C. There are then added 15 cc of phosphoric acid and the resulting reaction medium is cooled to -30° C. There are then slowly added, over a 35 minute period, while vigorously agitating, 9.7 cc of nitric acid (d=1.52) in 1.5 cc of sulfuric acid (d=1.83). The reaction mixture is then poured over 3 kgs of shaved ice to precipitate the desired product which is separated by filtration, washed with water and dried, yielding 47 g of product.

1. customthe resulting reaction medium
2. additionThere are then slowly added, over a 35 minute period
3. additionThe reaction mixture is then poured over 3 kgs of shaved ice
4. customto precipitate the desired product which
5. customis separated by filtration
6. washwashed with water
7. customdried