Acetic Acid → HCID 13079860, compound

Participants

Reaction Steps

Hydrogen peroxide (100 vol.; 65.6 ml) was added to glacial acetic acid (250 ml) with stirring and the solution was heated to 50°. 5-(p-Chlorophenyl-2-methyl-3-ethoxycarbonylpyridine (27.55 g) was added and the solution stirred at 50°-55° for 16 hours. The volume of the solution was halved by evaporation in vacuo at below 50° C., and the mixture was then poured into water and neutralised with 2M-sodium hydroxide. The precipitate so formed was filtered off and washed with water to give a white solid which was recrystallied from carbon tetrachloride to give, as white crystals, the title compound, m.p. 130°.

Provenance & Evidence