HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-aminomethyl-7-methoxy-3,4-dihydronaphthalene HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one | HCID 81276 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | HCID 12262631 | HCID 12262631 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-aminomethyl-7-methoxy-3,4-dihydronaphthalene HCl | HCID 12262633 | — |
Reaction Steps
25 g. of 7-methoxy-1,2,3,4-tetrahydro-1-naphthalenone is reacted with trimethylsilylcyanide and then with lithium aluminum hydride as described in Example 1 to yield 28 g. of 1-aminomethyl-1-hydroxy-7-methoxy-1,2,3,4-tetrahydronaphthalene. This compound is treated with HCl in ethanol as described in Example 3 to give 1-aminomethyl-7-methoxy-3,4-dihydronaphthalene HCl; m.p. 174°-175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04473586 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-7259cc4d32054aae8394cc9cc2cc0b82 |
| Source note | uspto-grants-1984_09 |