Trimethylsilyl cyanide → HCID 20445315, compound

Participants

Reaction Steps

6-amino-1,2,3,4-tetrahydro-1-naphthalenone is reacted with trimethylsilylcyanide followed by lithium aluminum hydride to obtain 1-aminomethyl-1-hydroxy-6-amino-1,2,3,4-tetrahydronaphthalene. This diamine is di-acetylated with acetic anhydride, chlorinated with chlorine and acetic acid, and then heated to dehydrate the alcohol. The resulting di-chloro-di-acetamide is hydrolyzed in HCl to obtain 1-aminomethyl-6-amino-5,7-dichloro-3,4-dihydronaphthalene HCl.

Provenance & Evidence