Hydrochloric Acid → HCID 70507074, compound

Participants

Reaction Steps

5-amino-6-benzyloxy-1,2,3,4-tetrahydro-1-naphthalenone (such as that disclosed in U.S. Pat. No. 4,035,512) is reacted with trimethylsilylcyanide followed by lithium aluminum hydride. The resultant 1-hydroxy-1- aminomethyl compound is dehydrated with HCl to give 1-aminomethyl-5-amino-6-benzyloxy-3,4-dihydronaphthalene HCl. This latter compound is reacted with trifluoro acetic anhydride to give 1-trifluoroacetylaminomethyl-5-amino-6-benzyloxy-3,4-dihydronaphthalene. This latter compound is formylated with formic acid and acetic anhydride and the trifluoroacetyl group is removed with Na2CO3 to yield 1-aminomethyl-5-formamido 6-benzyloxy-3,4-dihydronaphthalene HCl.

Provenance & Evidence