HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-amino-4-phenylbutanoate → 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-amino-4-phenylbutanoate | HCID 4646380 | — |
| Reactant | Ethyl 2-(2,3-dioxo-4,5-dihydro-1-benzazepin-1-yl)acetate | HCID 13500724 | — |
| Product | 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one | HCID 13243517 | — |
Reaction Steps
Ethyl 2-amino-4-phenylbutyrate is treated under conditions of reductive alkylation as described in the previous examples with 1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepine-2,3-dione to give 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one of example 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04473575 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-1780c5a938ba4fccbfc125391b6318b5 |
| Source note | uspto-grants-1984_09 |