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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418765Generated: November 1, 2026

Potassium Carbonate → 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one

https://huagongshe.com/reaction/2418765

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
ReactantEthyl 2-amino-4-phenylbutanoateHCID 4646380—
Reactant3-bromo-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-oneHCID 13339963—
SolventDichloromethaneHCID 6344—
Product1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-oneHCID 13243517—

Reaction Steps

Ethyl 2-amino-4-phenylbutyrate is treated in the presence of potassium carbonate in methylene chloride with 3-bromo-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one to give 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H[1]benzazepin-2-one of example 10.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04473575
Source datasetuspto-grants-1984_09
ORD IDord-d179d67ddc4542d2a1be222974c16a73
Source noteuspto-grants-1984_09