{(3S)-3-[(tert-Butoxycarbonyl)amino]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl}acetic acid → HCID 53796192, compound

Participants

Reaction Steps

A solution of 3-(S)-t-butyloxycarbonylamino-1-carboxymethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (5 g) in ethanol (100 ml) was hydrogenated at 45 psi using 5% rhodium on carbon (2 g) as catalyst, until uptake ceased. The catalyst was filtered off (celite) and the solvent removed under pressure to give 3-(S)-t-butyloxycarbonylamino-1-carboxymethyl-2,3,4,5,5a,6,7,8,9,9a-decahydro-1H-[1]benzazepin-2-one which was used without further purification for the next synthetic step.

Provenance & Evidence