Morpholine → HCID 44654287, compound

HRID 2418776Notes

Reaction equation

HRID 2418776 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][C:9]=1[S:17]([O-:20])(=[O:19])=[O:18].[Na+:21]>[Cl-].[Na+]>[O:4]1[CH2:5][CH2:6][N:1]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][C:9]=2[S:17]([O-:20])(=[O:19])=[O:18])[CH2:2][CH2:3]1.[Na+:21]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 70350Benzenesulfonic acid, 2-chloro-5-nitro-, sodium salt (1:1)

Product 1

HCID 44654287HCID 44654287, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 5234Sodium ChlorideSolvent

Conditions

Temperature
110 °C

Procedure

To 80 ml of morpholine, 82.5 g (0.3 mol) of sodium 2-chloro-5-nitrobenzenesulfonate was added with stirring. The reaction mixture was heated at about 110° C. on an oil bath with stirring for 30 minutes. After cooling, 100 ml of a saturated aqueous sodium chloride solution was added to the mixture. The crystals thus-precipitated were collected by filtration and washed with acetone to obtain 88 g (yield: 90%) of sodium 2-morpholino-5-nitrobenzenesulfonate.

Workup

  1. stirringwith stirring for 30 minutes
  2. temperatureAfter cooling
  3. customThe crystals thus-precipitated
  4. filtrationwere collected by filtration
  5. washwashed with acetone

Sources & evidence

ORD record
ord-ed83ef4db903440894807c762e76f550
Source dataset
uspto-grants-1984_09
Patent number
US04473632

Reaction notes

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