Diisopropylethylamine → (R)-3-(6-Methoxy-pyridin-3-yl)-3-[6-(5-methyl-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-propan-1-ol

Participants

Reaction Steps

A reaction mixture of 4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine (45 mg, 0.17 mmol) and (R)-3-amino-3-(6-methoxypyridin-3-yl)propan-1-ol (31 mg, 0.17 mmol) (prepared similarly according to the method for Intermediate 10) in acetonitrile (2 mL) and N,N-diisopropylethylamine (60 μL, 0.34 mmol) was subjected to microwave irradiation at 180° C. for 1 h. The reaction mixture was concentrated and purified by semi-prep HPLC to give a light yellow foam.

Provenance & Evidence