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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418856Generated: October 26, 2026

4-Acetylpyridine → 1-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-one

https://huagongshe.com/reaction/2418856

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-AcetylpyridineHCID 14282—
ReactantCID 89600919HCID 89600919—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
SolventWaterHCID 962—
SolventDichloromethaneHCID 6344—
Product1-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-oneHCID 5851610865%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja211422g
Source datasetMinisci dataset from Roche
ORD IDord-24043f9eb4064b3b8242f778d5cc6992
Source noteMinisci dataset from Roche