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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418857Generated: October 26, 2026

4-Acetylpyridine → 1-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-one

https://huagongshe.com/reaction/2418857

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-AcetylpyridineHCID 14282—
ReactantCID 89600919HCID 89600919—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
SolventDimethyl SulfoxideHCID 679—
SolventWaterHCID 962—
Product1-[2-(Difluoromethyl)pyridin-4-yl]ethan-1-oneHCID 5851610833%
ProductEthanone, 1-[3-(difluoromethyl)-4-pyridinyl]-HCID 11777850422%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja211422g
Source datasetMinisci dataset from Roche
ORD IDord-6cecc8b4ad5f464a803f171a898f82ab
Source noteMinisci dataset from Roche